Randomised Response-Adaptive Designs in Clinical Trials PDF ePub eBook

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Randomised Response-Adaptive Designs in Clinical Trials free pdf Randomised Response-Adaptive Designs in Clinical Trials presents methods for the randomised allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training. After introducing clinical trials in drug development, the authors assess a simple adaptive design for binary responses without covariates. They discuss randomisation and covariate balance in normally distributed responses and cover many important response-adaptive designs for binary responses. The book then develops response-adaptive designs for continuous and longitudinal responses, optimum designs with covariates, and response-adaptive designs with covariates. It also covers response-adaptive designs that are derived by optimising an objective function subject to constraints on the variance of estimated parametric functions. The concluding chapter explores future directions in the development of adaptive designs.

About Anthony C Atkinson

Anthony C. Atkinson is an Emeritus Professor of Statistics at the London School of Economics and Political Science. Atanu Biswas is a professor in the Applied Statistics Unit at the Indian Statistical Institute, Kolkata.

Details Book

Author : Anthony C Atkinson
Publisher : Chapman
Data Published : 26 December 2013
ISBN : 1584886943
EAN : 9781584886945
Format Book : PDF, Epub, DOCx, TXT
Number of Pages : pages
Age + : 15 years
Language : English
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