DNA Methylation and Cellular Differentiation PDF ePub eBook

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DNA Methylation and Cellular Differentiation free pdf In 1977 I wrote a grant proposal in which I applied to study developmental patterns in enzymatic methylation of DNA in eukaryotes. One part of the proposal was to assay cells at different embryonic developmental stages for maintenance and de novo type methylase activity. With one exception the referees, probably developmental biologists, recommended that the work not be supported because there was no evidence that methylation plays any role in eukaryotic gene regulation. Aside from proving that innovative ideas can seldom be used to successfully compete for grant funds, the skepticism of biologists toward methylation as a regulatory mechanism was, and still is, widespread even among some of those who investigate the problem. That is a healthy situation for all points of view should be brought to bear on a problem of such importance. However, to deny funds to investigate a problem because one has already formed an opinion without evidence is hardly commendable. The great skepticism about the significance of DNA methylation is based in part on the evidence that it is absent or very little used in Drosophila, a favorite organism for genetic and developmental studies. There now remains little doubt that methylation of cytosine in certain CpG sites can strikingly affect the transcription of sequences 3' to the methylated doublet. How this inhibition operates and to what extent it is utilized in cells is still debatable.

About James H. Taylor

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Details Book

Author : James H. Taylor
Publisher : Springer Verlag GmbH
Data Published : 31 December 1984
ISBN : 3211817611
EAN : 9783211817612
Format Book : PDF, Epub, DOCx, TXT
Number of Pages : 138 pages
Age + : 15 years
Language : English
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  • DNA Methylation and Cellular Differentiation free pdfDNA Methylation and Cellular Differentiation

    . In 1977 I wrote a grant proposal in which I applied to study developmental patterns in enzymatic methylation of DNA in eukaryotes. One part of the proposal was to assay cells at different embryonic